![]() Furthermore, the ADMET, PAINS, and PASS evaluation was carried out to select more potent hits. Further, high-affinity hits against CK1α were obtained based on their binding affinity score. First, a cluster of compounds was retrieved based on physicochemical parameters following Lipinski’s rules and PAINS filter. ![]() Here, we have performed virtual screening of phytoconstituents from the IMPPAT database seeking potential inhibitors of CK1α. The elevated expression of CK1α in diseased conditions facilitates its selective targeting for therapeutic management. It has been known to involve in the progression of many diseases, including cancer, neurodegeneration, obesity, and behavioral disorders. ![]() It is involved in various signaling pathways associated with chromosome segregation, cell metabolism, cell cycle progression, apoptosis, autophagy, etc. Casein kinase-1 alpha (CK1α) is a multifunctional protein kinase that belongs to the serine/threonine kinases of the CK1α family.
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